Madhura Kulkarni, PhD.
Breast cancer is one of the highest lifetime risks and the most common cause of cancer death amongst women worldwide. In India, 27% of all the cancer deaths happen due to breast cancer and 50% of these cases are below age 50 with majority below 37, unlike that of western countries. With PhD in Molecular Genetics and extensive experience in translational breast cancer research Dr. Kulkarni has a unique set of expertise to contribute to the translational research scene of Breast Cancer specific to Indian Subcontinent. Dr. Kulkarni’s translational research at the centre aims to understand casuals genetic and molecular alterations in Indian breast cancer, which may lead to developing India specific novel diagnostic regimes.
Senior Scientist and DBT-Ramalingaswami Fellow
Center for Translational Cancer Research
Prashanti Cancer Care Mission and
Indian Institute of Science Education and Research (IISER) Pune,
Dr. Homi Bhabha Road, Pune, Maharashtra 411021, India
Phone: +91 (20) 25908099
Areas of expertise
Cancer Biology and Signalling
2018 – 2022 DBT Ramalingaswami Fellowship. INR 88 lac – Ongoing.
2014 – 2017 B2B NUHS, In collaboration with Prof. Yoshiaki Ito and A/Prof. Lee Soo Chin.
(Conceived and wrote the grant) SGD $100,000.
2003 – 2008 PhD in Cell Biology and Molecular genetics. (GPA: 4.00) , University of Maryland, College Park. USA.
2000 – 2002 Masters in Science. University of Pune, India. Gold Medalist.
1997 – 2000 Bachelors in Science V. G. Vaze College, University of Mumbai, India. 3rd rank.
2014 – 2017 Senior Research Fellow. LKC School of Medicine, NTU, Singapore
2011 – 2014 Research Fellow. Cancer Science Institute. National University of Singapore
2009 – 2010 Postdoctoral Fellow. Harvard Medical School, Cell Biology Department and Massachusetts General Hospital, Cancer Center.
2003 – 2008 Graduate Research Assistant at Department of Cell Biology and Molecular genetics.
University of Maryland, College Park and CARB-UMBI, USA
2002 – 2003 Junior Research Fellow at Tata Institute of Fundamental Research, Mumbai. India
Fellowships and Awards
2017 Ramalingaswami ‘re-entry’ fellowship from DBT, India.
2004 – 2008 Graduate Research Assistantship. CARB, UMBI
2003 – 2004 Graduate Scholarship, CBMG, UMCP
2002 – 2003 Junior Research Fellowship, TIFR, Mumbai.
2003 Dr. T. S. Mahabale award of Gold Medal for securing outstanding grades in MSc Botany examination at University of Pune, India.
2002 Council for Scientific and Industrial Research – Junior Research Fellowship.
And selected amongst top 2% students from this National level test conducted by Government of India
2001 Milind Gandhi scholarship for MSc Second year.
1994 One year scholarship for being amongst top 30 in state level talent search.
Kulkarni A., Kelkar D.A., Parikh N., Shashidhara L.S., Koppiker C.B., Kulkarni M. (2020). Meta-analysis of prevalence of Triple Negative Breast Cancer and its clinical features at incidence in Indian Breast Cancer Patients. JCO Global Oncology (in press).
Qianqian He, Bijin Au, Madhura Kulkarni, Yang Shen, Kah J. Lim, Jiamila Maimaiti, Cheng Kit Wong, Giulia Rancati, Indrajit Sinha, Zhiyan Fu, Xiaomeng Wang, John E. Connolly and Karen C. Crasta. Chromosomal instability-induced senescence potentiates cell non-autonomous tumorigenic effects. (Oncogenesis: Manuscript accepted, Impact factor, Impact factor 4.7)
Rekha Jakhar, Monique N.H. Luijten, Alex X.F. Wong, Bing Cheng, Suat Neo, Bijin Au, Madhura Kulkarni, Kah J. Lim, Jiamila Maimaiti, Han C. Chong, Elaine H. Lim, Tee B. K. Tan, Kong W. Ong, Yirong Sim, Jill S. L. Wong, James B.K. Khoo, Juliana T.S. Ho, Ke Guo1, Boon T. Chua, Indrajit Sinha, Xiaomeng Wang John E. Connolly, Jayantha Gunaratne and Karen C. Crasta. Autophagy governs pro-tumourigenic effects of mitotic slippage-1 induced senescence. (Manuscript accepted in Molecular Cancer Research, Impact factor 6.2)
Madhura Kulkarni, Tuan Zea Tan, Nurfarhanah Sulaiman, John Lamar, Prashali Bansal, Jianzhou Cui, Yiting Qiao, Yoshiaki Ito. RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer. Oncotarget. (Impact factor 5.16) 2018; 9:14175-14192
Vaidehi Krishnan, Yu Lin Chong, Tuan Zea Tan, Madhura Kulkarni, Muhammad Bakhait Bin Rahmat, Lavina Sierra Tay, Haresh Sankar, Doorgesh Jokhun, Amudha Ganesan, Linda Shyue Huey Chuang, Dominic Voon, G V Shivashankar, Jean Paul Thiery, and Yoshiaki Ito. TGF-β promotes genomic instability upon RUNX3 deficiency. Cancer Research (Impact factor 9.3) 2018 Jan 1;78(1):88-102
Gandhi Theerthagiri, Madhura Kulkani, Ho Sze Yuan, Adrian Boey, Edmond Wei Min Chua, Veluchamy A. Barathi, Tom J. Carney, Xiaomeng Wang and Wanjin Hong. Cavin-2 regulates the activity and stability of eNOS in angiogenesis. J Bio Chem (Impact factor 4.57) 2017 Sep 14.
Madhura Kulkarni, Shakes DC, Guevel K, Smith Harold E. SPE-44 implements sperm cell fate. PLoS Genetics (Impact Factor 9.17). 2012 Apr;8(4):e1002678.
Peter Mulligan, Fajun Yang, Luisa Di Stefano, Jun-Yuan Ji, Jian Ouyang, Joy L Nishikawa, Qun Wang, Madhura Kulkarni, S. Hani Najafi-Shoushtari, Raul Mostoslavsky, Steven P Gygi, Grace Gill, Nicholas J Dyson, Anders M Näär. A SIRT1-LSD1 Co-repressor Complex Regulates Notch Target Gene Expression and Development. Molecular Cell. (Impact Factor 14.2). 2011 Jun 10;42(5):689-99.
Alexander G. Milbradt, Madhura Kulkarni*, Tingfang Yi*, Koh Takeuchi, Zhen-Yu J. Sun, Rafael Luna, Philipp Selenko, Anders M. Näär and Gerhard Wagner. Structure of the VP16 Transactivator Target in ARC/Mediator. Nat Struct Mol Biol. (Impact Factor 12.7) 2011 Apr;18 (4):410-5.
Madhura Kulkarni1, Antonio Del-Castillo1, and Harold Smith. Regulation of sperm gene expression by the GATA factor ELT-1. Dev. Biol. (Impact Factor 4.05) 2009 July 8;doi:10.1016/j.ydbio.2009.06.044. (1: Shared Lead author),
Madhura Kulkarni and Harold Smith. E1 Ubiquitin-Activating Enzyme UBA-1 plays multiple roles throughout C. elegans development. PLoS Genetics. (Impact factor 9.17) 2008 July 18;4(7):e1000131.
Anindya Ghosh-Roy, Madhura Kulkarni, Vikash Kumar, Seema Shirolikar, and Krishanu Ray. Cytoplasmic Dynein–Dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila. Mol. Biol. Cell. (Impact factor 5.7) 2004 Vol. 15, Issue 5, 2470-2483.
Madhura Kulkarni, S. Dighe, A. Sawant, P. Oswal , K. Sahsrabuddhe, A. Patwardhan Institutions : Biodiversity Hotspots in Urban Areas. 2001 (An extended abstract published in the proceedings of International Conference on Tropical Ecosystems at Bangalore, India.)